Infertility is a rising global health issue with a far‐reaching impact on the socioeconomic
livelihoods. As there are highly complex causes of male and female infertility, it is highly …

Introduction. Premature ovarian failure (POF) can occur naturally at an early age or be due
to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to …

Oxidative stress, generated by excessive reactive oxygen species (ROS) or decreased
antioxidant defenses (and possibly both), is associated with male infertility. Oxidative stress …

Considerable challenges in engineering the female reproductive tissue are the follicle's
unique architecture, the need to recapitulate the extracellular matrix, and tissue …

Folliculogenesis is a complex process that requires integration of autocrine, paracrine, and
endocrine factors together with tightly regulated interactions between granulosa cells and …

Contemporary systems for in vitro culture of ovarian follicles do not recapitulate the
mechanical heterogeneity in mammalian ovary. Here we report microfluidic generation of …

Reproduction is the most important event for the continuation of life. Unfortunately, infertility
is a widespread problem. Recently, biomaterials have been widely used in reproductive …

Fertility preservation is an important type of frontier scientific research in the field of
reproductive health. The culture of ovarian cortices to i) initiate primordial follicle growth and …

The in vivo function and phenotype of ovarian follicle cells are determined by many factors.
When these cells are removed from the in vivo microenvironment and grown in a 2D in vitro …

Ovarian failure is the most common cause of infertility. Although numerous strategies have
been proposed, a definitive solution for recovering ovarian functions and restoring fertility is …