▪ Abstract Telomere molecular biology is far more complex than originally thought.
Understanding biological systems is aided by study of evolutionary variants, and Drosophila …

Drosophila telomeres comprise DNA sequences that differ dramatically from those of other
eukaryotes. Telomere functions, however, are similar to those found in telomerase‐based …

Interest in the field of epigenetics has increased rapidly over the last decade, with the term
becoming more identifiable in biomedical research, scientific fields outside of the molecular …

Wnt/Wingless signaling controls many fundamental processes during animal development.
Wnt transduction is mediated by the association of β-catenin with nuclear TCF DNA binding …

The centromere-specific histone variant CENP-A (CID in Drosophila) is a structural and
functional foundation for kinetochore formation and chromosome segregation. Here, we …

The centromere is essential for proper segregation and inheritance of genetic information.
Centromeres are generally regulated to occur exactly once per chromosome; failure to do so …

The maintenance of chromosome ends in Drosophila is an exceptional phenomenon
because it relies on the transposition of specialized retrotransposons rather than on the …

Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end
fusion despite the absence of all telomere-associated sequences. The sequence …

Telomeres prevent chromosome ends from being repaired as double‐strand breaks (DSBs).
Telomere identity in Drosophila is determined epigenetically with no sequence either …

In most organisms, telomeres are extended by telomerase and contain GC-rich repeats.
Drosophila telomeres are elongated by occasional transposition of specialized …