The first genuine high-resolution single particle cryo-electron microscopy structure of a
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …

The sodium/potassium-ATPase (NKA) is the enzyme that establishes gradients of sodium
and potassium across the plasma membrane. NKA activity is tightly regulated for different …

For proteins, the sequence→ structure→ function paradigm applies primarily to enzymes,
transmembrane proteins, and signaling domains. This paradigm is not universal, but rather …

Multidomain proteins with long flexible linkers and full-length intrinsically disordered
proteins (IDPs) are best defined as an ensemble of conformations rather than a single …

Receptor-like kinases (RLKs) are the most numerous signal transduction components in
plants and play important roles in determining how different plants adapt to their ecological …

Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs
via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by …

Arrestin-dependent pathways are a central component of G protein-coupled receptor
(GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be …

The emergence of B. cereus as an opportunistic food-borne pathogen has intensified the
need to distinguish strains of public health concern. The heterogeneity of the diseases …

Background The N-terminal regulatory element (NRE) of Receptor-like kinases (RLKs),
consisting of the juxtamembrane segment in receptor kinases (RKs) and the N-terminal …

Plasmodium vivax malaria affects 14 million people each year. Its invasion requires
interactions between the parasitic Duffy-binding protein (Pv DBP) and the N-terminal …