Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation
K Van Roey, B Uyar, RJ Weatheritt, H Dinkel… - Chemical …, 2014 - ACS Publications
The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …
mediate the functions required for cell viability. Specific, context-dependent and tightly …
Using data‐independent, high‐resolution mass spectrometry in protein biomarker research: perspectives and clinical applications
In medicine, there is an urgent need for protein biomarkers in a range of applications that
includes diagnostics, disease stratification, and therapeutic decisions. One of the main …
includes diagnostics, disease stratification, and therapeutic decisions. One of the main …
[HTML][HTML] Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder
We present a new strategy for systematic identification of phosphotyrosine (pTyr) by affinity
purification mass spectrometry (AP-MS) using a Src homology 2 (SH2)-domain-derived pTyr …
purification mass spectrometry (AP-MS) using a Src homology 2 (SH2)-domain-derived pTyr …
Monobodies and other synthetic binding proteins for expanding protein science
Synthetic binding proteins are constructed using nonantibody molecular scaffolds. Over the
last two decades, in‐depth structural and functional analyses of synthetic binding proteins …
last two decades, in‐depth structural and functional analyses of synthetic binding proteins …
[HTML][HTML] SOS GEFs in health and disease
FC Baltanás, N Zarich, JM Rojas-Cabañeros… - … et Biophysica Acta (BBA …, 2020 - Elsevier
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange
factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins …
factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins …
Lessons from miR-143/145: the importance of cell-type localization of miRNAs
OA Kent, MN McCall, TC Cornish… - Nucleic acids …, 2014 - academic.oup.com
Abstract miR-143 and miR-145 are co-expressed microRNAs (miRNAs) that have been
extensively studied as potential tumor suppressors. These miRNAs are highly expressed in …
extensively studied as potential tumor suppressors. These miRNAs are highly expressed in …
Protein-protein interaction networks: probing disease mechanisms using model systems
U Kuzmanov, A Emili - Genome medicine, 2013 - Springer
Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the
cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs …
cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs …
Controlling entropy to tune the functions of intrinsically disordered regions
Highlights•High entropy of intrinsically disordered regions (IDRs) forms the basis for
functional plasticity.•Inherent features of IDRs are optimised to overcome the entropic cost of …
functional plasticity.•Inherent features of IDRs are optimised to overcome the entropic cost of …
Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells
H Sugiyama, K Takahashi… - Proceedings of the …, 2017 - National Acad Sciences
Novel APOBEC1 target 1 (Nat1)(also known as “p97,”“Dap5,” and “Eif4g2”) is a ubiquitously
expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic …
expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic …