The ribosome catalyzes two fundamental biological reactions: peptidyl transfer, the
formation of a peptide bond during protein synthesis, and peptidyl hydrolysis, the release of …

Bioconjugation reactions are critical to the modification of peptides and proteins, permitting
the introduction of biophysical probes onto proteins as well as drugs for use in antibody …

Over the years, several methods have been developed to effectively represent the chemical
behavior of solutes in solvents. The environmental effects arising due to solvation can …

A kinetic study is reported for aminolysis of X-substituted phenyl diphenylphosphinates (1a−
i) in 80 mol% H2O/20 mol% dimethyl sulfoxide at 25.0±0.1° C. The Brønsted-type plot for the …

The N-heterocyclic carbene and hydroxamic acid cocatalyzed kinetic resolution of cyclic
amines generates enantioenriched amines and amides with selectivity factors up to 127. In …

DFT calculations using a PCM solvation model were carried out to examine the reaction
pathways for the formation of carbamate from CO2 and monoethanolamine (MEA) in the …

The quality of reactivity predictions coming from alternative theoretical approaches as well
as experimental reactivity constants is examined in the case of the ester aminolysis process …

Pseudo-first-order rate constants (k obsd) have been measured spectrophotometrically for
nucleophilic substitution reactions of 1-X-2, 4-dinitrobenzenes (1a–d, X= F, Cl, Br, I) with …

Second-order rate constants (k N) were measured for aminolyses of Y-substituted-phenyl 2-
methoxybenzoates 2a–i and 4-nitrophenyl X-substituted-benzoates 3a–j in MeCN at 25.0° …

A kinetic study is reported for aminolysis of 4-pyridyl X-substituted-benzoates 5a–i. Plots of
pseudo-first-order rate constants (k obsd) vs [amine] curve upward for the reactions of …