To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits
to enhance phenotype-based drug discovery, to map the molecular origins of disease, and …

An engineered SOX17 variant with point mutations within its DNA binding domain termed
SOX17FNV is a more potent pluripotency inducer than SOX2, yet the underlying mechanism …

Cell segmentation is a major bottleneck in extracting quantitative single-cell information from
microscopy data. The challenge is exasperated in the setting of microstructured …

Connecting the molecular structure and function of chromatin across length and timescales
remains a grand challenge to understanding and engineering cellular behaviors. Across five …

Advances in synthetic biology have provided genetic tools to reprogram cells to obtain a
variety of desired cellular functions. These include tools to enable the customization of cells …

Biohybrid devices based on engineered cells interfaced with bioelectronics represent a
promising union where the strengths of each field can be synergistically combined, resulting …

Augmenting cells with novel, genetically encoded functions will support therapies that
expand beyond natural capacity for immune surveillance and tissue regeneration. However …

Time-lapse fluorescent microscopy (TLFM) combined with predictive mathematical
modelling is a powerful tool to study the inherently dynamic processes of life on the single …

Single cell biology has the potential to elucidate many critical biological processes and
diseases, from development and regeneration to cancer. Single cell analyses are …