CRISPR technologies for bacterial systems: current achievements and future directions

KR Choi, SY Lee - Biotechnology Advances, 2016 - Elsevier
Throughout the decades of its history, the advances in bacteria-based bio-industries have
coincided with great leaps in strain engineering technologies. Recently unveiled clustered …

[HTML][HTML] Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens

R Bhattacharjee, A Nandi, P Mitra, K Saha, P Patel… - Materials Today Bio, 2022 - Elsevier
Foodborne infection is one of the leading sources of infections spreading across the world.
Foodborne pathogens are recognized as multidrug-resistant (MDR) pathogens posing a …

Exploiting endogenous CRISPR-Cas system for multiplex genome editing in Clostridium tyrobutyricum and engineer the strain for high-level butanol production

J Zhang, W Zong, W Hong, ZT Zhang, Y Wang - Metabolic engineering, 2018 - Elsevier
Abstract Although CRISPR-Cas9/Cpf1 have been employed as powerful genome
engineering tools, heterologous CRISPR-Cas9/Cpf1 are often difficult to introduce into …

Regional Salmonella Differences in United States Broiler Production from 2016 to 2020 and the Contribution of Multiserovar Populations to Salmonella Surveillance

AT Siceloff, D Waltman, NW Shariat - Applied and Environmental …, 2022 - Am Soc Microbiol
Poultry remains a considerable source of foodborne salmonellosis despite significant
reduction of Salmonella incidence during processing. There are multiple entry points for …

CRISPR-cas3 of Salmonella Upregulates Bacterial Biofilm Formation and Virulence to Host Cells by Targeting Quorum-Sensing Systems

L Cui, X Wang, D Huang, Y Zhao, J Feng, Q Lu, Q Pu… - Pathogens, 2020 - mdpi.com
Salmonella is recognized as one of the most common microbial pathogens worldwide. The
bacterium contains the clustered regularly interspaced short palindromic repeats (CRISPR) …

Comprehensive blueprint of Salmonella genomic plasticity identifies hotspots for pathogenicity genes

S Krishnakant Kushwaha, Y Wu, H Leonardo Avila… - Plos …, 2024 - journals.plos.org
Understanding the dynamic evolution of Salmonella is vital for effective bacterial infection
management. This study explores the role of the flexible genome, organised in regions of …

Exploiting heterologous and endogenous CRISPR‐Cas systems for genome editing in the probiotic Clostridium butyricum

X Zhou, X Wang, H Luo, Y Wang… - Biotechnology and …, 2021 - Wiley Online Library
Clostridium butyricum has been widely used as a probiotic for humans and food animals.
However, the mechanisms of beneficial effects of C. butyricum on the host remain poorly …

Delivery of CRISPR-Cas systems using phage-based vectors

C Fage, N Lemire, S Moineau - Current opinion in biotechnology, 2021 - Elsevier
Highlights•Antimicrobial resistance requires new therapeutic strategies.•CRISPR-Cas
systems can be repurposed as antimicrobials.•Phages can be used as delivery vehicles of …

Biomapping Salmonella serovar complexity in broiler carcasses and parts during processing

S Rasamsetti, NW Shariat - Food Microbiology, 2023 - Elsevier
Salmonella contamination of poultry remains a food safety challenge for broiler processors.
The objectives of this study were to measure the efficacy of antimicrobial interventions in …

Combined quantification and deep serotyping for Salmonella risk profiling in broiler flocks

T Obe, AT Siceloff, MG Crowe, HM Scott… - Applied and …, 2023 - Am Soc Microbiol
Despite a reduction of Salmonella contamination on final poultry products, the level of
human salmonellosis cases attributed to poultry has remained unchanged over the last few …