Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Sleep deprivation (SD) is increasingly common in modern society, which can lead to the
dysregulation of inflammatory responses and cognitive impairment, but the mechanisms …

Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Apolipoprotein E (ApoE) is a multifaceted secreted molecule synthesized in the CNS by
astrocytes and microglia, and in the periphery largely by the liver. ApoE has been shown to …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

As the population ages, the number of people with dementia is expected to increase in the
coming decades, with consequences at the societal and individual levels. In this narrative …

Cognitive impairment, and dementia, are major contributors to global burden of death and
disability, with projected increases in prevalence in all regions of the world, but most marked …

Abstract Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is associated with onset of neurological and psychiatric symptoms during and after the …

Depression is a heterogeneous mental disorder characterized by feelings of sadness and
loss of interest that render the subject unable to handle basic daily activities such as …