The role of taurine in mitochondria health: more than just an antioxidant

CJ Jong, P Sandal, SW Schaffer - Molecules, 2021 - mdpi.com
Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in
excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first …

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

YY Wu, HC Kuo - Journal of Biomedical Science, 2020 - Springer
Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or-7

S McComb, PK Chan, A Guinot, H Hartmannsdottir… - Science …, 2019 - science.org
Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic
cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the …

[HTML][HTML] Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

H Zhao, C Li, L Li, J Liu, Y Gao… - Molecular …, 2020 - spandidos-publications.com
Baicalin is an important flavonoid compound THAT is isolated from the Scutellaria
baicalensis Georgi Chinese herb and plays a critical role in anti‑oxidative, anti‑inflammatory …

Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells

SS Jia, GP Xi, M Zhang, YB Chen… - Oncology …, 2013 - spandidos-publications.com
D-limonene is recognized as a potential chemotherapeutic agent, however, the details of
this mechanism remain unclear. In this study, we investigated the effects of d-limonene on …

Revisiting regulated cell death responses in viral infections

DAB Rex, TS Keshava Prasad… - International journal of …, 2022 - mdpi.com
The fate of a viral infection in the host begins with various types of cellular responses, such
as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and …

CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis

HK An, KM Chung, H Park, J Hong, JE Gim, H Choi… - Autophagy, 2020 - Taylor & Francis
ABSTRACT CASP9 (caspase 9) is a well-known initiator caspase which triggers intrinsic
apoptosis. Recent studies also suggest various non-apoptotic roles of CASP9, including …

Polystyrene microplastics induced ovarian toxicity in juvenile rats associated with oxidative stress and activation of the PERK-eIF2α-ATF4-CHOP signaling pathway

W Wang, J Guan, Y Feng, S Liu, Y Zhao, Y Xu, H Xu… - Toxics, 2023 - mdpi.com
Numerous reports confirm that microplastics exposure could induce reproductive toxicity in
mammals. However, the effects of microplastics exposure during juveniles on ovarian …

A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

Z Liu, J Xu, J He, Y Zheng, H Li, Y Lu… - Blood, The Journal …, 2014 - ashpublications.org
Hedgehog (Hh) signaling plays an important role in the oncogenesis of B-cell malignancies
such as multiple myeloma (MM). However, the source of Hh ligand sonic hedgehog (SHH) …

NF‐kappaB dimers in the regulation of neuronal survival

I Sarnico, A Lanzillotta, M Benarese, M Alghisi… - International review of …, 2009 - Elsevier
Nuclear factor‐kappaB (NF‐κB) is a dimeric transcription factor composed of five members,
p50, RelA/p65, c‐Rel, RelB, and p52 that can diversely combine to form the active …