Unravelling G protein‐coupled receptor signalling networks using global phosphoproteomics
R Pokhrel, AL Morgan, HR Robinson… - British Journal of …, 2024 - Wiley Online Library
G protein‐coupled receptor (GPCR) activation initiates signalling via a complex network of
intracellular effectors that combine to produce diverse cellular and tissue responses …
intracellular effectors that combine to produce diverse cellular and tissue responses …
FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2
K Tsuji-Tamura, M Ogawa - Angiogenesis, 2023 - Springer
The forkhead box O1 (FOXO1) is an important transcription factor related to proliferation,
metabolism, and homeostasis, while the major phenotype of FOXO1-null mice is abnormal …
metabolism, and homeostasis, while the major phenotype of FOXO1-null mice is abnormal …
Ubiquitin-driven G protein-coupled receptor inflammatory signaling at the endosome
N Cheng, JM Pimentel, JA Trejo - American Journal of …, 2024 - journals.physiology.org
G protein-coupled receptors (GPCRs) are ubiquitously expressed cell surface receptors that
mediate numerous physiological responses and are highly druggable. Upon activation …
mediate numerous physiological responses and are highly druggable. Upon activation …
An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses
G protein–coupled receptors (GPCRs) are highly druggable and implicated in numerous
diseases, including vascular inflammation. GPCR signals are transduced from the plasma …
diseases, including vascular inflammation. GPCR signals are transduced from the plasma …
Crassostrea gigas-Based Bioactive Peptide Protected Thrombin-Treated Endothelial Cells against Thrombosis and Cell Barrier Dysfunction
The activation of thrombin-treated endothelial cells resulted in disruption of the vascular
tissues. A novel oyster-derived bioactive dodecapeptide (IEELEELEAER, P-2-CG) was …
tissues. A novel oyster-derived bioactive dodecapeptide (IEELEELEAER, P-2-CG) was …
[HTML][HTML] PAR1 regulates sepsis-induced vascular endothelial barrier dysfunction by mediating ERM phosphorylation via the RhoA/ROCK signaling pathway
L Zhao, J Hu, P Zheng, B Mi, Z Chen, X Zhao… - International …, 2023 - Elsevier
Sepsis begins with vascular endothelial barrier breakdown and causes widespread organ
failure. Protease-activated receptor 1 (PAR1) is an important target for modulating vascular …
failure. Protease-activated receptor 1 (PAR1) is an important target for modulating vascular …
Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β
D Melamed Kadosh, J Beenstock, D Engelberg… - International Journal of …, 2023 - mdpi.com
The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various
cellular responses to stress conditions, inflammatory signals, and differentiation factors …
cellular responses to stress conditions, inflammatory signals, and differentiation factors …
p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production
T Zheng, J Deng, J Wen, S Xiao, H Huang… - Communications …, 2024 - nature.com
Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell
infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse …
infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse …
Quantitative modeling of signaling in aggressive B cell lymphoma unveils conserved core network
B Klinger, I Rausch, A Sieber, H Kutz… - PLOS Computational …, 2024 - journals.plos.org
B cell receptor (BCR) signaling is required for the survival and maturation of B cells and is
deregulated in B cell lymphomas. While proximal BCR signaling is well studied, little is …
deregulated in B cell lymphomas. While proximal BCR signaling is well studied, little is …
Integrative phosphoproteomic analyses reveal hemostatic-endothelial signaling interplay
SA Groten, BL van den Eshof, FPJ van Alphen… - Journal of Thrombosis …, 2024 - Elsevier
Background The vascular endothelial cell (EC) monolayer plays a crucial part in maintaining
hemostasis. An extensive array of G protein-coupled receptors allows ECs to dynamically …
hemostasis. An extensive array of G protein-coupled receptors allows ECs to dynamically …