Perforin and granzymes: function, dysfunction and human pathology
A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …
potent toxins, including the pore-forming protein perforin and serine protease granzymes …
The mystery behind membrane insertion: a review of the complement membrane attack complex
C Bayly-Jones, D Bubeck… - … Transactions of the …, 2017 - royalsocietypublishing.org
The membrane attack complex (MAC) is an important innate immune effector of the
complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite …
complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite …
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin
C Leung, NV Dudkina, N Lukoyanova, AW Hodel… - elife, 2014 - elifesciences.org
Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins
constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors …
constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors …
Structure of the poly-C9 component of the complement membrane attack complex
The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is
the major component of the MAC, a multi-protein complex that forms pores in the membrane …
the major component of the MAC, a multi-protein complex that forms pores in the membrane …
Conformational changes during pore formation by the perforin-related protein pleurotolysin
N Lukoyanova, SC Kondos, I Farabella, RHP Law… - PLoS …, 2015 - journals.plos.org
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily
of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble …
of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble …
The pore conformation of lymphocyte perforin
Perforin is a pore-forming protein that facilitates rapid killing of pathogen-infected or
cancerous cells by the immune system. Perforin is released from cytotoxic lymphocytes …
cancerous cells by the immune system. Perforin is released from cytotoxic lymphocytes …
The unique molecular choreography of giant pore formation by the cholesterol-dependent cytolysins of Gram-positive bacteria
RK Tweten, EM Hotze, KR Wade - Annual review of …, 2015 - annualreviews.org
The mechanism by which the cholesterol-dependent cytolysins (CDCs) assemble their giant
β-barrel pore in cholesterol-rich membranes has been the subject of intense study in the …
β-barrel pore in cholesterol-rich membranes has been the subject of intense study in the …
Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins
MA Dunstone, RK Tweten - Current opinion in structural biology, 2012 - Elsevier
The bacterial cholesterol dependent cytolysins (CDCs) and membrane attack
complex/perforin-like proteins (MACPF) represent two major branches of a large …
complex/perforin-like proteins (MACPF) represent two major branches of a large …
Structural journey of an insecticidal protein against western corn rootworm
G Marini, B Poland, C Leininger, N Lukoyanova… - Nature …, 2023 - nature.com
The broad adoption of transgenic crops has revolutionized agriculture. However, resistance
to insecticidal proteins by agricultural pests poses a continuous challenge to maintaining …
to insecticidal proteins by agricultural pests poses a continuous challenge to maintaining …
[HTML][HTML] Giant MACPF/CDC pore forming toxins: a class of their own
Abstract Pore Forming Toxins (PFTs) represent a key mechanism for permitting the passage
of proteins and small molecules across the lipid membrane. These proteins are typically …
of proteins and small molecules across the lipid membrane. These proteins are typically …