Cancer vaccines: Building a bridge over troubled waters

MLC Sellars, CJ Wu, EF Fritsch - Cell, 2022 - cell.com
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …

Targeting the stimulator of interferon genes (STING) in breast cancer

M Ying-Rui, B Bu-Fan, L Deng, S Rong… - Frontiers in …, 2023 - frontiersin.org
Breast cancer has a high occurrence rate globally and its treatment has demonstrated
clinical efficacy with the use of systemic chemotherapy and immune checkpoint blockade …

[HTML][HTML] Highly multiplexed spatially resolved proteomic and transcriptional profiling of the glioblastoma microenvironment using archived formalin-fixed paraffin …

Y Kim, P Danaher, PJ Cimino, K Hurth, S Warren… - Modern Pathology, 2023 - Elsevier
Glioblastoma is a heterogeneous tumor for which effective treatment options are limited and
often insufficient. Few studies have examined the intratumoral transcriptional and proteomic …

Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment context

J Czapla, A Drzyzga, S Matuszczak, T Cichoń… - Frontiers in …, 2023 - frontiersin.org
Introduction Targeting tumor vasculature is an efficient weapon to fight against cancer;
however, activation of alternative pathways to rebuild the disrupted vasculature leads to …

Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

R Serrano, M Lettau, M Zarobkiewicz, D Wesch… - …, 2022 - Taylor & Francis
ABSTRACT Ligands for Stimulator of Interferon Genes (STING) receptor are under
investigation as adjuvants in cancer therapy. Multiple effects have been described, including …

Recent progress in cancer immunotherapy: Application of nano-therapeutic systems

R Ghafelehbashi, M Salehi, M Kouhi… - Journal of Drug Delivery …, 2024 - Elsevier
Cancer immunotherapy is a hopeful strategy that seeks to enhance the immune system's
capacity to detect, manage, and eradicate cancerous cells. It has shown promise in halting …

[HTML][HTML] Differential Response to Local Stimulator of Interferon Genes Agonist Administration in Tumors with Various Stimulator of Interferon Genes Statuses

A Drzyzga, J Czapla, S Matuszczak, B Łasut-Szyszka… - Cancers, 2025 - mdpi.com
Abstract Background/Objectives: The stimulator of interferon genes (STING) is currently
accepted as a relevant target for anti-cancer therapies. Besides encouraging results …

[PDF][PDF] 宫颈癌患者人乳头瘤病毒感染情况及STING、 ZEB1 蛋白水平分析

岳彩霞, 梁文华, 张秉虹, 李润峰 - 中国微生态学杂志, 2023 - cjm.dmu.edu.cn
阳泉市第三人民医院病理科, 山西045000 摘要: 目的分析宫颈癌患者人乳头瘤病毒(HPV)
感染情况及癌灶组织内干扰素基因刺激因子(STING), E 盒锌指结合蛋白1 (ZEB1) 表达情况 …

Deciphering the Double-Edged Action of STING pathway in Cancer

N Datta - Inquiry: The University of Arkansas Undergraduate …, 2024 - scholarworks.uark.edu
Cancer cells have unstable chromosomes and damaged DNA, which can activate the
cellular alarm system cGAS-STING. This mechanism detects DNA in the incorrect location …

Human papillomavirus infection and levels of STING and ZEB1 proteins in patients with cervical cancer

YUE Cai-xia, L Wen-hua, Z Bing-hong… - Chinese Journal of …, 2023 - cjm.dmu.edu.cn
Objective To analyze human papillomavirus (HPV) infection and the levels of stimulator of
interferon genes (STING) and zinc-finger E-box binding protein 1 (ZEB1) in patients with …