Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

The increasing prevalence of depression and diabetes mellitus has become a major public
health problem worldwide. Studies have shown that people with diabetes are at a high risk …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …

Pancreatic beta cells are the only cell type in our body capable of producing and secreting
insulin to instruct the insulin-sensitive cells and tissues of our bodies to absorb nutrients after …

Macrophages reside in specific territories in organs, where they contribute to the
development, homeostasis, and repair of tissues. Recent work has shown that the size of …

Worldwide, since ages and nowadays, traditional medicine is well known, owing to its
biodiversity, which immensely contributed to the advancement and development of …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …