Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Background: Communication within a protein complex is mediated by physical interactions
made among the protomers. Evidence for both the allosteric regulation present among the …

Background Autosomal-dominant mutations in the Park8 gene encoding Leucine-rich repeat
kinase 2 (LRRK2) have been identified to cause up to 40% of the genetic forms of …

Abstract F17464 (N-(3-{4-[4-(8-Oxo-8H-[1, 3]-dioxolo-[4, 5-g]-chromen-7-yl)-butyl]-piperazin-
1-yl}-phenyl)-methanesulfonamide, hydrochloride) is a new potential antipsychotic with a …

Eukaryotic membranes can be partitioned into lipid-driven membrane microdomains called
lipid rafts, which function to sort lipids and proteins in the plane of the membrane. As protein …

Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5% of
individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified …

G-Protein coupled receptors (GPCRs) are involved in a myriad of pathways key for human
physiology through the formation of complexes with intracellular partners such as G-proteins …

With increasing life expectancy, a growing number of individuals are being affected by
Parkinson's Disease (PD), a Neurodegenerative Disease (ND). Approximately, 5–10% of PD …

Semaphorins (SEMAs) and their Plexin (PLXN) receptors are central regulators of metazoan
cellular communication. SEMA-PLXND1 signaling plays important roles in cardiovascular …

G protein-coupled receptors (GPCRs) are ubiquitously expressed transmembrane proteins
associated with a wide range of diseases such as Alzheimer's, Parkinson, schizophrenia …