With the identification of ChREBP in 2001, our interest in understanding the molecular
control of carbohydrate sensing has surged. While ChREBP was initially studied as a master …

Retinoic acid–related orphan receptor γt (RORγt) functions as a ligand-dependent
transcription factor that regulates multiple proinflammatory genes and plays a critical role in …

Abstract Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells
in a glucose dependent manner. Several pathways mediate this action by rapid, kinase …

Cholesterol and its metabolites are bioactive lipids that interact with and regulate the activity
of various proteins and signaling pathways that are implicated in the control of a variety of …

Excessive sugar consumption is a contributor to the worldwide epidemic of cardiometabolic
disease. Understanding mechanisms by which sugar is sensed and regulates metabolic …

Objectives Thyroid hormone (T3) and high glucose concentrations are critical components of
β-cell maturation and function. In the present study, we asked whether T3 and glucose …

Aims/hypothesis Chronic exposure of pancreatic beta cells to high glucose and fatty acids
has been proposed to induce glucolipotoxicity. However, contradictory results suggest …

The ability to predict transcription factors based on sequence information in regulatory
elements is a key step in systems-level investigation of transcriptional regulation. Here, we …

Identification of the Mondo glucose-responsive transcription factors family, including the
MondoA and MondoB/ChREBP paralogs, has shed light on the mechanism whereby …

Although the mechanisms by which glucose regulates insulin secretion from pancreatic β-
cells are now well described, the way glucose modulates gene expression in such cells …