Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

A Cuadrado, AI Rojo, G Wells, JD Hayes… - Nature reviews Drug …, 2019 - nature.com
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

TC Theoharides, C Cholevas, K Polyzoidis… - Biofactors, 2021 - Wiley Online Library
COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome
associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome …

Secondary metabolites profiled in cannabis inflorescences, leaves, stem barks, and roots for medicinal purposes

D Jin, K Dai, Z Xie, J Chen - Scientific reports, 2020 - nature.com
Cannabis research has historically focused on the most prevalent cannabinoids. However,
extracts with a broad spectrum of secondary metabolites may have increased efficacy and …

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

D Kempuraj, R Thangavel, DD Kempuraj… - Biofactors, 2021 - Wiley Online Library
Neuroinflammation leads to neurodegeneration, cognitive defects, and neurodegenerative
disorders. Neurotrauma/traumatic brain injury (TBI) can cause activation of glial cells …

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

AE Odieka, GU Obuzor, OO Oyedeji, M Gondwe… - Molecules, 2022 - mdpi.com
Cannabis sativa is known among many cultures for its medicinal potential. Its complexity
contributes to the historical application of various parts of the plant in ethno-medicines and …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Mast cells, neuroinflammation and pain in fibromyalgia syndrome

TC Theoharides, I Tsilioni, M Bawazeer - Frontiers in Cellular …, 2019 - frontiersin.org
Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain,
accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive …

Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and …

T Mokhtari, M Lu, AEM El-Kenawy - International Immunopharmacology, 2023 - Elsevier
This study aimed to examine the effects of luteolin (LUT) on chronic neuropathic pain (NP)-
induced mood disorders (ie, anxiety and depression) by regulating oxidative stress …

Recent advances in our understanding of mast cell activation–or should it be mast cell mediator disorders?

TC Theoharides, I Tsilioni, H Ren - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …