Why do the two sexes have different lifespans and rates of aging? Two hypotheses based
on asymmetric inheritance of sex chromosomes (“unguarded X”) or mitochondrial genomes …

For almost 40 years, studies of whole-organism performance have formed a cornerstone of
evolutionary physiology. Although its utility as a heuristic guide is beyond question, and we …

Nutrition has long been considered more the domain of medicine and agriculture than of the
biological sciences, yet it touches and shapes all aspects of the natural world. The need for …

Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a
larger effect in females than males. Traditionally, this has been attributed to a stronger trade …

Organisms from slime moulds to humans carefully regulate their macronutrient intake to
optimize a wide range of life history characters including survival, stress resistance, and …

Dietary restriction (DR) without malnutrition is widely regarded to be a universal mechanism
for prolonging lifespan. It is generally believed that the benefits of DR arise from eating fewer …

Dietary restriction extends lifespan in a variety of organisms, but the key nutritional
components driving this process and how they interact remain uncertain. In Drosophila …

Background Behavioural phenotypes vary within and among individuals. While early-life
experiences have repeatedly been proposed to underpin interactions between these two …

Nutritional geometry has shown the benefits of viewing nutrition in a multidimensional
context, in which foraging is viewed as a process of balancing the intake and use of multiple …

Classic theories of ageing consider extrinsic mortality (EM) a major factor in shaping
longevity and ageing, yet most studies of functional ageing focus on species with low EM …