Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens
(NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of …

Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue
to do so despite negative consequences. Even after prolonged periods of abstinence …

The last two decades have witnessed substantial advances in identifying synaptic plasticity
responsible for behavioral changes in animal models of substance use disorder. We have …

Information processing in the brain requires multiple forms of synaptic plasticity that
converge on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR) …