Reticular pseudodrusen: a critical phenotype in age-related macular degeneration

Z Wu, EL Fletcher, H Kumar, U Greferath… - Progress in retinal and …, 2022 - Elsevier
Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct
lesions that occur in the subretinal space. Over the past three decades, their presence in …

Inherited retinal diseases: therapeutics, clinical trials and end points—a review

M Georgiou, K Fujinami… - Clinical & Experimental …, 2021 - Wiley Online Library
Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of
disorders characterised by photoreceptor degeneration or dysfunction. These disorders …

Subretinal drusenoid deposits AKA pseudodrusen

RF Spaide, S Ooto, CA Curcio - Survey of ophthalmology, 2018 - Elsevier
A distinction between conventional drusen and pseudodrusen was first made in 1990, and
more recently knowledge of pseudodrusen, more accurately called subretinal drusenoid …

Congenital stationary night blindness: an analysis and update of genotype–phenotype correlations and pathogenic mechanisms

C Zeitz, AG Robson, I Audo - Progress in retinal and eye research, 2015 - Elsevier
Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …

Clinical applications of fundus autofluorescence in retinal disease

M Yung, MA Klufas, D Sarraf - International journal of retina and vitreous, 2016 - Springer
Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical
practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the …

The role of vitamin A in retinal diseases

J Sajovic, A Meglič, D Glavač, Š Markelj… - International journal of …, 2022 - mdpi.com
Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is
essential for several physiological processes. Either hyper-or hypovitaminosis can be …

Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological …

KN Khan, OA Mahroo, RS Khan, MD Mohamed… - Progress in retinal and …, 2016 - Elsevier
Drusen are discussed frequently in the context of their association with age-related macular
degeneration (AMD). Some types may, however, be regarded as a normal consequence of …

Pseudodrusen subtypes as delineated by multimodal imaging of the fundus

M Suzuki, T Sato, RF Spaide - American journal of ophthalmology, 2014 - Elsevier
Purpose To subclassify pseudodrusen based on their appearance in multimodal imaging.
Design Retrospective, observational series. Methods The color fundus photographs and …

Negative electroretinograms: genetic and acquired causes, diagnostic approaches and physiological insights

X Jiang, OA Mahroo - Eye, 2021 - nature.com
The dark-adapted human electroretinogram (ERG) response to a standard bright flash
includes a negative-going a-wave followed by a positive-going b-wave that crosses the …

Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration

M Housset, A Samuel, M Ettaiche… - Journal of …, 2013 - Soc Neuroscience
Photoreceptors are specialized neurons of the retina that receive nursing from the adjacent
retinal pigment epithelium (RPE). Frequent in the elderly, photoreceptor loss can originate …