The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …

Background: B-cell receptor (BCR) signaling is crucial for normal B-cell development and
adaptive immunity. In chronic lymphocytic leukemia (CLL), the malignant B cells display …

In chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on
microenvironmental signals at lymphoid sites where the crosstalk between the integrin VLA …

Simple Summary Mutations of the NOTCH1 gene are a validated prognostic marker in
chronic lymphocytic leukemia and a potential predictive marker for anti-CD20-based …

Simple Summary Chronic lymphocytic leukemia (CLL) clones contain cells differing in age:
recently born, proliferative (PF), intermediate (IF), and resting (RF) fractions. We used …

Introduction The leukemic cells of patients with chronic lymphocytic leukemia (CLL) are often
unique, expressing remarkably similar IGHV-IGHD-IGHJ gene rearrangements,“stereotyped …

The leukemic B cells from patients with chronic lymphocytic leukemia (CLL) require
interactions with non‐malignant cells and matrix in the tissue microenvironment to survive …

Chronic lymphocytic leukemia (CLL) is a disease of the elderly, often presenting
comorbidities like osteoporosis and requiring, in a relevant proportion of cases, treatment …

Simple Summary The goal of this review is to describe the biological and clinical
implications associated with the analysis of the immunoglobulin (also known as B-cell …

Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients
with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that …