Voltage-gated sodium channel dysfunctions in neurological disorders
The pore-forming subunits (α subunits) of voltage-gated sodium channels (VGSC) are
encoded in humans by a family of nine highly conserved genes. Among them, SCN1A …
encoded in humans by a family of nine highly conserved genes. Among them, SCN1A …
Heterogeneity of cellular senescence: cell type-specific and senescence stimulus-dependent epigenetic alterations
KM Kwiatkowska, E Mavrogonatou, A Papadopoulou… - Cells, 2023 - mdpi.com
The aim of the present study was to provide a comprehensive characterization of whole
genome DNA methylation patterns in replicative and ionizing irradiation-or doxorubicin …
genome DNA methylation patterns in replicative and ionizing irradiation-or doxorubicin …
Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons
Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor
neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we …
neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we …
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back
M De Bellis, B Boccanegra, AG Cerchiara… - International Journal of …, 2023 - mdpi.com
The voltage-gated sodium channels represent an important target for drug discovery since a
large number of physiological processes are regulated by these channels. In several …
large number of physiological processes are regulated by these channels. In several …
Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells
Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron disease with a monogenic cause
in approximately 10% of cases. However, familial clustering of disease without inheritance in …
in approximately 10% of cases. However, familial clustering of disease without inheritance in …