The mammalian brain is the most complex organ in the body. It controls all aspects of our
bodily functions and interprets the world around us through our senses. It defines us as …

In bilaterally symmetric organisms, the midline is a critical organizing center for the
developing central nervous system. There is a striking conservation of the molecules and …

Clearing techniques have been developed to transparentize mouse brains, thereby
preserving 3D structure, but their complexity has limited their use. Here, we show that …

Loss-of-function mutations in UPF3B result in variable clinical presentations including
intellectual disability (ID, syndromic and non-syndromic), autism, childhood onset …

Direct Laser Writing (DLW) is an innovative tool that allows the photofabrication of high
resolution 3D structures, which can be successfully exploited for the study of the physical …

Axons must switch responsiveness to guidance cues during development for correct
pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons ventrally toward …

Commissural neurons project axons across the floor plate at the spinal cord ventral midline.
After crossing, commissural axons turn rostrally, sort into distinct positions within the …

Pioneer axons from the cingulate cortex initiate corpus callosum (CC) development, yet
nothing is known about the molecules that regulate their guidance. We demonstrate that …

How brain connectivity has evolved to integrate the mammalian-specific neocortex remains
largely unknown. Here, we address how dorsal thalamic axons, which constitute the main …

Astrocytes are the most abundant glial cells in the central nervous system. These cells are
an important hub for intercellular communication. They participate in various …