Pulmonary arterial hypertension: pathogenesis and clinical management
Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology
Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV …
ventricular (RV) function. Although pulmonary load is an important determinant of RV …
Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
MM Redfield, HH Chen, BA Borlaug, MJ Semigran… - Jama, 2013 - jamanetwork.com
Importance Studies in experimental and human heart failure suggest that
phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise …
phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise …
Beyond erectile dysfunction: cGMP-specific phosphodiesterase 5 inhibitors for other clinical disorders
Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …
Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …
The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure
The right ventricle (RV) is the major determinant of functional state and prognosis in
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …
Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
Background—Prominent features of myocardial remodeling in heart failure with preserved
ejection fraction (HFPEF) are high cardiomyocyte resting tension (Fpassive) and …
ejection fraction (HFPEF) are high cardiomyocyte resting tension (Fpassive) and …
Diagnosis and assessment of pulmonary arterial hypertension
DB Badesch, HC Champion… - Journal of the American …, 2009 - jacc.org
The diagnosis and assessment of pulmonary arterial hypertension is a rapidly evolving area,
with changes occurring in the definition of the disease, screening and diagnostic techniques …
with changes occurring in the definition of the disease, screening and diagnostic techniques …
Signaling effectors underlying pathologic growth and remodeling of the heart
JH Van Berlo, M Maillet… - The Journal of clinical …, 2013 - Am Soc Clin Investig
Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …
responds to many cardiopathological conditions with hypertrophic growth by enlarging …
Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study
Background—The prevalence of heart failure with preserved ejection fraction is increasing.
The prognosis worsens with pulmonary hypertension and right ventricular (RV) failure …
The prognosis worsens with pulmonary hypertension and right ventricular (RV) failure …