Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …

The purpose of this paper is to provide a brief overview of current thinking on the role of
connexins, in particular Cx43, in growth regulation, and a more detailed discussion as to …

Despite the tremendous amount of data over the last 40years, lack of gap junctional
intercellular communication (GJIC) or altered expression of gap junction proteins is still a …

Abstract Connexin 43 (Cx43) is present at the sarcolemma and the inner membrane of
cardiomyocyte subsarcolemmal mitochondria (SSM). Lack or inhibition of mitochondrial …

Breakdown of the skin barrier requires the recognition of and rapid responses to invading
pathogens. Since wounding usually also affects endothelial intactness, the expression of …

Transgenic CBA mice expressing either the tyrosine kinase GTK (gut tyrosine kinase) or the
adaptor protein SHB (Src homology 2 protein of beta-cells) under the control of the rat …

Both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), its
animal model, involve inflammatory attack on central nervous system (CNS) white matter …

Cardiac conduction is mediated by gap junction channels that are formed by connexin (Cx)
protein subunits. The connexin family of proteins consists of more than 20 members varying …

Increased leukocyte trafficking into the parenchyma during inflammatory responses in the
central nervous system (CNS) is facilitated by the extracellular proteolytic activities of matrix …