Current progress in the derivation and therapeutic application of neural stem cells

Y Tang, P Yu, L Cheng - Cell death & disease, 2017 - nature.com
Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …

Neurogenesis in the aging brain

DM Apple, R Solano-Fonseca, E Kokovay - Biochemical pharmacology, 2017 - Elsevier
Adult neurogenesis is the process of producing new neurons from neural stem cells (NSCs)
for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular …

Stem cells: a promising candidate to treat neurological disorders

CG Song, YZ Zhang, HN Wu, XL Cao… - Neural regeneration …, 2018 - journals.lww.com
Neurologic impairments are usually irreversible as a result of limited regeneration in the
central nervous system. Therefore, based on the regenerative capacity of stem cells …

Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases

DGT Parambi, KS Alharbi, R Kumar, S Harilal… - Molecular …, 2022 - Springer
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function

M Mendivil‐Perez, V Soto‐Mercado… - Journal of pineal …, 2017 - Wiley Online Library
Neural stem cells (NSC s) are regarded as a promising therapeutic approach to protecting
and restoring damaged neurons in neurodegenerative diseases (ND s) such as Parkinson's …

Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB …

SS Josiah, CD Famusiwa, OO Crown, AO Lawal… - Neurotoxicology, 2022 - Elsevier
The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …

Regulation of microglia function by neural stem cells

MMA de Almeida, K Goodkey… - Frontiers in Cellular …, 2023 - frontiersin.org
Neural stem and precursor cells (NPCs) build and regenerate the central nervous system
(CNS) by maintaining their pool (self-renewal) and differentiating into neurons, astrocytes …

Ex vivo gene therapy for the treatment of neurological disorders

G Gowing, S Svendsen, CN Svendsen - Progress in brain research, 2017 - Elsevier
Ex vivo gene therapy involves the genetic modification of cells outside of the body to
produce therapeutic factors and their subsequent transplantation back into patients. Various …

Neural stem cell grafts promote astroglia-driven neurorestoration in the aged parkinsonian brain via Wnt/β-catenin signaling

F L'episcopo, C Tirolo, L Peruzzotti-Jametti… - Stem Cells, 2018 - academic.oup.com
During aging—one the most potent risk factors for Parkinson's disease (PD)—both
astrocytes and microglia undergo functional changes that ultimately hamper homoeostasis …

Human neural stem cell transplantation rescues cognitive defects in APP/PS1 model of Alzheimer's disease by enhancing neuronal connectivity and metabolic activity

X Li, H Zhu, X Sun, F Zuo, J Lei, Z Wang… - Frontiers in aging …, 2016 - frontiersin.org
Alzheimer's disease (AD), the most frequent type of dementia, is featured by Aβ pathology,
neural degeneration and cognitive decline. To date, there is no cure for this disease. Neural …