It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

Highlights•SIRT3, a major deacetylase in mitochondria, regulates almost every aspect of
mitochondrial health and functionality.•SIRT3 controls vital functions like energy balance …

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC)
death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting
both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple …

SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial
proteins including metabolic enzymes and respiratory chain components. Although SIRT3's …

Osteoporosis is a common metabolic disease that has a high incidence in postmenopausal
women. Studies have indicated that oxidative damage plays an important role in the …