Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Transforming growth factor (TGF)-β uses several intracellular signaling pathways besides
canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several …

Systemic sclerosis (SSc) is a severe auto-immune disease, characterized by vasculopathy
and fibrosis of connective tissues. SSc has a high morbidity and mortality and unfortunately …

In response to tissue injury, fibroblasts differentiate into professional repair cells called
myofibroblasts, which orchestrate many aspects of the normal tissue repair programme …

Systemic sclerosis (SSc, scleroderma) is a complex connective tissue disorder characterized
by multisystem clinical manifestations resulting from immune dysregulation/autoimmunity …

Background Prolonged activation of dermal fibroblasts is the main cause of progressive
fibrosis in systemic sclerosis (SSc). It seems that inhibition of apoptosis in SSc fibroblasts …

The pathogenesis of many diseases is influenced by environmental factors which can affect
human genome and be inherited from generation to generation. Adverse environmental …

ABSTRACT Introduction Systemic sclerosis (SSc) is a systemic disease encompassing
autoimmunity, vasculopathy, and fibrosis. SSc is still burdened by high mortality and …

BACKGROUND: Elderly people often suffer from sleep disorders. Chamomile due to the
many health benefits such as sedation may be effective in improving sleep quality in elderly …