Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Glucocorticoids are steroid hormones produced by the adrenal cortex and are essential for
the maintenance of various metabolic and homeostatic functions. Their function is regulated …

Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Glucocorticoids modulate the feto-maternal interface during the induction of parturition. In
the dog, the prepartum rise of cortisol in the maternal circulation appears to be erratic, and …

In early pregnancy, the placenta anchors the conceptus and supports embryonic
development and survival. This study aimed to investigate the underlying functions of Shh …

Monogenic disorders of hypertension are a distinct group of diseases causing dysregulation
of the renin–angiotensin–aldosterone system and are characterized by low plasma renin …

Context Complex steroid disorders such as P450 oxidoreductase deficiency or apparent
cortisone reductase deficiency may be recognized by steroid profiling using …

Context: Polycystic ovary syndrome (PCOS) is a heritable, complex genetic disease. Animal
models suggest that androgen exposure at critical developmental stages contributes to …

Maternal stress has been linked to infant birth weight outcomes, which itself may be
associated with health later in life. The placenta acts as a master regulator for the fetal …

The comprehensive evaluation of the adrenal steroidogenic pathway, given its complexity,
requires methodology beyond the standard techniques currently employed. Advances in LC …