Usually the dense extracellular structure in fibrotic tissues is described as extracellular
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …

There is an unmet need for high‐quality liquid biomarkers that can safely and reproducibly
predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The …

Adipocytes represent a major cell type in the mammary tumor microenvironment and are
important for tumor growth. Collagen VI (COL6) is highly expressed in adipose tissue …

Mutations in the three canonical collagen VI genes, COL6A1, COL6A2 and COL6A3, cause
a spectrum of muscle disease from Bethlem myopathy at the mild end to the severe Ullrich …

Objective Chondrocytes, the sole cell type in articular cartilage, maintain the extracellular
matrix (ECM) through a homeostatic balance of anabolic and catabolic activities that are …

Fibrosis is recognized as the major pathological change in adipose tissue during the
development of obesity. However, the detailed mechanisms governing the interactions …

The α-chains of the collagen superfamily are encoded with information that specifies self-
assembly into fibrils, microfibrils, and networks that have diverse functions in the …

Here we describe three novel collagen VI chains, α4, α5, and α6. The corresponding genes
are arranged in tandem on mouse chromosome 9. The new chains structurally resemble the …

We report the identification of three new collagen VI genes at a single locus on human
chromosome 3q22. 1. The three new genes are COL6A4, COL6A5, and COL6A6 that …

Background Muscle mass and function are perturbed by immobilization and remobilization.
When muscle mass changes, the quality and quantity of the extracellular matrix protein …