Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes
Highlights•Small self-cleaving ribozymes are essential for rolling-circle-based replication of
satellite and pathogenic RNAs.•Structure–function research on active site alignments and …
satellite and pathogenic RNAs.•Structure–function research on active site alignments and …
Rational design of nonbonded point charge models for divalent metal cations with Lennard-Jones 12-6 potential
Exploring a metal-involved biochemical process at a molecular level often requires a
reliable description of metal properties in aqueous solution by classical nonbonded models …
reliable description of metal properties in aqueous solution by classical nonbonded models …
FRET-guided modeling of nucleic acids
FD Steffen, RA Cunha, RKO Sigel… - Nucleic Acids …, 2024 - academic.oup.com
The functional diversity of RNAs is encoded in their innate conformational heterogeneity.
The combination of single-molecule spectroscopy and computational modeling offers new …
The combination of single-molecule spectroscopy and computational modeling offers new …
Advances in the field of RNA 3D structure prediction and modeling, with purely theoretical approaches, and with the use of experimental data
Recent advancements in RNA three-dimensional (3D) structure prediction have provided
significant insights into RNA biology, highlighting the essential role of RNA in cellular …
significant insights into RNA biology, highlighting the essential role of RNA in cellular …
A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus
Maintaining manganese (Mn) homeostasis is important for the virulence of numerous
bacteria. In the human respiratory pathogen Streptococcus pneumoniae, the Mn-specific …
bacteria. In the human respiratory pathogen Streptococcus pneumoniae, the Mn-specific …
Mimicking co-transcriptional RNA folding using a superhelicase
Tuesday, February 20, 2018 433a example, allows alternative conformation formation that is
otherwise inaccessible in thermal folding. Here, we developed a superhelicase-based …
otherwise inaccessible in thermal folding. Here, we developed a superhelicase-based …
Advances that facilitate the study of large RNA structure and dynamics by nuclear magnetic resonance spectroscopy
The characterization of functional yet nonprotein coding (nc) RNAs has expanded the role of
RNA in the cell from a passive player in the central dogma of molecular biology to an active …
RNA in the cell from a passive player in the central dogma of molecular biology to an active …
Revealing the distinct folding phases of an RNA three-helix junction
Remarkable new insight has emerged into the biological role of RNA in cells. RNA folding
and dynamics enable many of these newly discovered functions, calling for an …
and dynamics enable many of these newly discovered functions, calling for an …
Stepwise sRNA targeting of structured bacterial mRNAs leads to abortive annealing
EM Małecka, SA Woodson - Molecular cell, 2021 - cell.com
Bacterial small RNAs (sRNAs) regulate the expression of hundreds of transcripts via base
pairing mediated by the Hfq chaperone protein. sRNAs and the mRNA sites they target are …
pairing mediated by the Hfq chaperone protein. sRNAs and the mRNA sites they target are …