After decades of research and clinical trials there is still no cure for Alzheimer's disease
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …

Over 4 decades of research support the link between Alzheimer disease (AD) and
somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF and SRIF-expressing …

李林, 医学博士, 药理学教授, 博士生导师. 现任中国药理学会常务理事, 抗衰老与老年痴呆专业
委员会主任委员, 北京药理学会理事长和中国老年学学会老年医学委员会认知障碍专家委员会 …

Ageing is associated with a deterioration of cognitive performance and with increased risk of
neurodegenerative disorders. Hypertension is the most-prevalent modifiable risk factor for …

SIRT3 deacetylates mitochondrial proteins, thereby enhancing their function. We have
previously demonstrated that Sirt3 gene deletion leads to brain mitochondrial dysfunction …

Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper
functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE) …

The insulin-degrading enzyme (IDE) gene is a strong positional and biological candidate for
late-onset Alzheimer disease (LOAD) susceptibility, with recent studies independently …

To evaluate the therapeutic effects of Chinese herbal medicine (CHM) for Alzheimer's
disease (AD), we evaluated five CHMs in oligomeric A β 2 5− 3 5-treated mouse primary …

Chronic exposure to glucocorticoids might result not only in insulin resistance or cognitive
deficits, but it is also considered as a risk factor for pathologies such as Alzheimer's disease …