COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics
Purpose The coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8
million lives across the world and raised a major global health concern. We survey the …
million lives across the world and raised a major global health concern. We survey the …
Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules
AP Kourounakis, D Xanthopoulos… - Medicinal Research …, 2020 - Wiley Online Library
Morpholine is a heterocycle featured in numerous approved and experimental drugs as well
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
and the associated disease COVID-19, requires therapeutic interventions that can be rapidly …
and the associated disease COVID-19, requires therapeutic interventions that can be rapidly …
Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases
The sigma-1 (σ1) receptor, an enigmatic protein originally classified as an opioid receptor
subtype, is now understood to possess unique structural and functional features of its own …
subtype, is now understood to possess unique structural and functional features of its own …
Morpholine as a scaffold in medicinal chemistry: an update on synthetic strategies
A Tzara, D Xanthopoulos, AP Kourounakis - ChemMedChem, 2020 - Wiley Online Library
Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged
structural component of bioactive molecules. This is mainly due to its contribution to a …
structural component of bioactive molecules. This is mainly due to its contribution to a …
Occurrence of morpholine in central nervous system drug discovery
E Lenci, L Calugi, A Trabocchi - ACS Chemical Neuroscience, 2021 - ACS Publications
Developing drugs for the central nervous system (CNS) requires fine chemical modifications,
as a strict balance between size and lipophilicity is necessary to improve the permeability …
as a strict balance between size and lipophilicity is necessary to improve the permeability …
Sigma 1 receptor: a new therapeutic target for pain
Abstract Sigma 1 receptor (σ 1 receptor) is a unique ligand-regulated molecular chaperone
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …
located mainly in the endoplasmic reticulum and the plasma membrane. σ 1 receptor is …
[HTML][HTML] Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice
Sigma-1 (σ1) receptors play a role in different types of pain and in central sensitization
mechanisms; however, it is unknown whether they are involved in chemotherapy-induced …
mechanisms; however, it is unknown whether they are involved in chemotherapy-induced …
Sigma 2 receptor/Tmem97 agonists produce long lasting antineuropathic pain effects in mice
Neuropathic pain is an important medical problem with few effective treatments. The sigma 1
receptor (σ1R) is known to be a potential target for neuropathic pain therapeutics, and …
receptor (σ1R) is known to be a potential target for neuropathic pain therapeutics, and …