Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …

There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and
squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin …

So far, two genes associated with familial melanoma have been identified, accounting for a
minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of …

Melanoma is the most lethal form of skin cancer, and the incidence and mortality rates are
rapidly rising. Epidemiologically, high numbers of nevi (moles) are associated with higher …

The molecular biology of metastatic potential in melanoma has been studied many times
previously and changes in the expression of many genes have been linked to metastatic …

Pathway-specific therapy is the future of cancer management. The oncogenic
phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; …

Background: Gene expression profiling data for human primary cutaneous melanomas are
scarce because of the lack of retrospective collections of frozen tumors. To identify …

Purpose: The incidence of malignant melanoma is increasing worldwide in fair-skinned
populations. Melanomas respond poorly to systemic therapy, and metastatic melanomas …

Thyroid cancer poses a significant clinical challenge, and our understanding of its
pathogenesis is incomplete. To gain insight into the pathogenesis of papillary thyroid …

Purpose Our purpose was development and assessment of a BRAF-mutant gene
expression signature for colon cancer (CC) and the study of its prognostic implications …