Abstract The coronavirus disease 2019 (COVID-19) pandemic caused and is still causing
significant mortality and economic consequences all over the globe. As of today, there are …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

Pyroptosis is a proinflammatory form of cell death that is associated with pathogenesis of
many chronic inflammatory diseases. Melatonin is substantially reported to possess anti …

Sepsis is one of the most important causes of death in intensive care units. Despite the fact
that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the
production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …