Exposing synonymous mutations

RC Hunt, VL Simhadri, M Iandoli, ZE Sauna… - Trends in Genetics, 2014 - cell.com
Synonymous codon changes, which do not alter protein sequence, were previously thought
to have no functional consequence. Although this concept has been overturned in recent …

In silico methods for predicting functional synonymous variants

BC Lin, U Katneni, KI Jankowska, D Meyer… - Genome Biology, 2023 - Springer
Single nucleotide variants (SNVs) contribute to human genomic diversity. Synonymous
SNVs are previously considered to be “silent,” but mounting evidence has revealed that …

ComiR: combinatorial microRNA target prediction tool

C Coronnello, PV Benos - Nucleic acids research, 2013 - academic.oup.com
ComiR is a web tool for combinatorial microRNA (miRNA) target prediction. Given an
messenger RNA (mRNA) in human, mouse, fly or worm genomes, ComiR computes the …

miR-1207-5p Can Contribute to Dysregulation of Inflammatory Response in COVID-19 via Targeting SARS-CoV-2 RNA

G Bertolazzi, C Cipollina, PV Benos… - Frontiers in Cellular …, 2020 - frontiersin.org
The present study focuses on the role of human miRNAs in SARS-CoV-2 infection. An
extensive analysis of human miRNA binding sites on the viral genome led to the …

DeepLNC, a long non-coding RNA prediction tool using deep neural network

R Tripathi, S Patel, V Kumari, P Chakraborty… - … Modeling Analysis in …, 2016 - Springer
The significant role of long non-coding RNAs (lncRNAs) in various cellular functions, such
as gene imprinting, immune response, embryonic pluripotency, tumorogenesis, and genetic …

Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts

L Huleihel, A Ben-Yehudah… - … of Physiology-Lung …, 2014 - journals.physiology.org
MicroRNAs are small noncoding RNAs that inhibit protein expression. We have previously
shown that the inhibition of the microRNA let-7d in epithelial cells caused changes …

Micro RNA‐146a and micro RNA‐155 as novel crevicular fluid biomarkers for periodontitis in non‐diabetic and type 2 diabetic patients

N Radović, N Nikolić Jakoba, N Petrović… - Journal of Clinical …, 2018 - Wiley Online Library
Aim Recent studies point at the crucial role of epigenetic mechanisms in the development of
multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition …

Overexpression of microRNA-1 promotes cardiomyocyte commitment from human cardiovascular progenitors via suppressing WNT and FGF signaling pathways

TY Lu, B Lin, Y Li, A Arora, L Han, C Cui… - Journal of molecular and …, 2013 - Elsevier
Early heart development takes place through a complex series of steps, including the
induction of cardiac mesoderm, formation of the cardiovascular progenitor cells and the …

Obesity‐induced mitochondrial dysfunction in porcine adipose tissue‐derived mesenchymal stem cells

Y Meng, A Eirin, XY Zhu, H Tang… - Journal of cellular …, 2018 - Wiley Online Library
Transplantation of autologous mesenchymal stem cells (MSCs) may be a viable option for
treatment of several diseases. MSCs efficacy depends on adequate function of their …

Computational characterization of osteoporosis associated SNPs and genes identified by genome-wide association studies

L Qin, Y Liu, Y Wang, G Wu, J Chen, W Ye, J Yang… - PloS one, 2016 - journals.plos.org
Objectives Genome-wide association studies (GWASs) have revealed many SNPs and
genes associated with osteoporosis. However, influence of these SNPs and genes on the …