Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

Transforming growth factor-beta (TGF-β) is a member of a family of secreted cytokines with
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …

Long non-coding RNAs (lncRNAs) were playing critical roles in tumorigenesis. However, in
prostate cancer, the roles and mechanisms of lncRNAs especially ANRIL were largely …

Wound healing requires static epithelial cells to gradually assume a mobile phenotype
through a multi-step process termed epithelial-to-mesenchymal transition (EMT). Although it …

Transforming growth factor β (TGF-β) family members play an extensive role in cellular
communication that orchestrates both early development and adult tissue homeostasis …

Advanced gastric cancer (GC) has a poor prognosis and its treatment strategies are not very
efficient. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) has emerged as a …

Simple Summary In addition to its role in development and in the vascular and
hematopoietic systems, ERG plays a central role in prostate cancer. Approximately 40–50 …

The long noncoding RNA ANRIL, located in the human chromosome 9p21 region, has been
reported to be involved in tumor progression. ANRIL regulates gene expression via …

Prostate cancer (PCa) is one of the most prevalent and malignant cancer types in men,
which causes more than three-hundred thousand cancer death each year. At late stage of …

In the past decade, multi-national and multi-center efforts were launched to sequence
prostate cancer genomes, transcriptomes, and epigenomes with the aim of discovering the …