IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Periphery and brain, innate and adaptive immunity in Parkinson's disease

AS Harms, SA Ferreira, M Romero-Ramos - Acta neuropathologica, 2021 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …

CD4+ T cells contribute to neurodegeneration in Lewy body dementia

D Gate, E Tapp, O Leventhal, M Shahid, TJ Nonninger… - Science, 2021 - science.org
Recent studies indicate that the adaptive immune system plays a role in Lewy body
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …

The contribution of microglia to neuroinflammation in Parkinson's disease

K Badanjak, S Fixemer, S Smajić, A Skupin… - International Journal of …, 2021 - mdpi.com
With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease

GP Williams, AM Schonhoff, A Jurkuvenaite… - Brain, 2021 - academic.oup.com
Abstract α-Synuclein, a key pathological component of Parkinson's disease, has been
implicated in the activation of the innate and adaptive immune system. This immune …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1−/− mice

D Matheoud, T Cannon, A Voisin, AM Penttinen… - Nature, 2019 - nature.com
Parkinson's disease is a neurodegenerative disorder with motor symptoms linked to the loss
of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that …

The immunology of Parkinson's disease

B Zhu, D Yin, H Zhao, L Zhang - Seminars in immunopathology, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …