The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

Background Cancer cachexia is largely irreversible, at least via nutritional means, and
responsible for 20–40% of cancer‐related deaths. Therefore, preventive measures are of …

Experimental evidence supports an intricate association between inflammation and
mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory …

Highlights•Cachexia and sarcopenia share common trends: altered protein synthesis and
degradation.•Cachexia and sarcopenia are both driven by inflammation.•Sarcopenia is …

Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Cachexia occurs in patients with advanced cancers. Despite the adverse clinical impact of
cancer-induced muscle wasting, pathways causing cachexia are controversial, and clinically …

Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …

IL-6 remains a promising therapeutic strategy for attenuating cachexia progression with
many types of cancer. However, improvement of this treatment will require a better …

Protein synthesis and degradation are dynamically regulated processes that act in concert to
control the accretion or loss of muscle mass. The present article focuses on the mechanisms …