Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …

The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance
of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation …

Background The reduction of tetrazolium salts by NAD (P) H to formazan product has been
widely used to determine the metabolic activity of cells, and as an indicator of cell viability …

We introduce a new class of semisynthetic fluorescent biosensors for the quantification of
free nicotinamide adenine dinucleotide (NAD+) and ratios of reduced to oxidized …

Breast cancer remains the second most lethal cancer among women in the United States
and triple-negative breast cancer is the most aggressive subtype with limited treatment …

NADH and NAD+ cofactors drive hundreds of biochemical reactions, and their ratio is a key
metabolic marker of cellular state. Traditional assays to measure the NADH/NAD+ ratio is …

Label-free characterization of cell subpopulations is a very promising biomedical approach.
Nowadays, there are several label-free methods based on different physical properties such …

Although the precise mechanisms determining the neurotoxic or neuroprotective activation
phenotypes in microglia remain poorly characterized, metabolic changes in these cells …

Sensing of intracellular NAD (P) H is important for numerous applications ranging from
diagnostic assays to drug discovery. Up to now, investigation of NAD (P) H-dependent …

NAD+ and NADH participate in many metabolic reactions. The NAD+/NADH ratio is an
important parameter reflecting the general metabolic and redox state of different types of …