Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells
JA Williams - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract The intracellular signaling mechanisms by which cholecystokinin (CCK) and other
secretagogues regulate pancreatic acinar function are more complex than originally …
secretagogues regulate pancreatic acinar function are more complex than originally …
Functions of the adapter protein Cas: signal convergence and the determination of cellular responses
AH Bouton, RB Riggins, PJ Bruce-Staskal - Oncogene, 2001 - nature.com
Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that
associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to …
associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to …
Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of …
JF Wang, IW Park, JE Groopman - Blood, The Journal of the …, 2000 - ashpublications.org
The stromal cell-derived factor-1 (SDF-1) is an alpha chemokine that binds to the CXCR4
receptor. Knock-out studies in mice demonstrate that this ligand-receptor pair is essential in …
receptor. Knock-out studies in mice demonstrate that this ligand-receptor pair is essential in …
PKC-δ and-ε regulate NF-κB activation induced by cholecystokinin and TNF-α in pancreatic acinar cells
A Satoh, AS Gukovskaya, JM Nieto… - American Journal …, 2004 - journals.physiology.org
Although NF-κB plays an important role in pancreatitis, mechanisms underlying its activation
remain unclear. We investigated the signaling pathways mediating NF-κB activation in …
remain unclear. We investigated the signaling pathways mediating NF-κB activation in …
Changes in tyrosine phosphorylation associated with true capacitation and capacitation‐like state in boar spermatozoa
MM Bravo, IM Aparicio… - Molecular …, 2005 - Wiley Online Library
Capacitation is defined as a series of events that render boar sperm competent to fertilize,
either in vivo or in vitro. Moreover, preliminary stages of cryopreservation of spermatozoa …
either in vivo or in vitro. Moreover, preliminary stages of cryopreservation of spermatozoa …
[HTML][HTML] Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-δ …
Protein kinase C-δ (PKC-δ) becomes activated in pancreatic acini in response to
cholecystokinin (CCK) and plays a pivotal role in the exocrine pancreatic secretion …
cholecystokinin (CCK) and plays a pivotal role in the exocrine pancreatic secretion …
Inhibition of phosphatidylinositol 3-kinase modifies boar sperm motion parameters
IM Aparicio, MC Gil, M Garcia-Herreros… - …, 2005 - rep.bioscientifica.com
Motility is the most widely used indicator of sperm quality. Besides modulation by the cAMP
pathway little is known regarding the intracellular pathways that regulate boar sperm motility …
pathway little is known regarding the intracellular pathways that regulate boar sperm motility …
[HTML][HTML] The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis …
B Nuche-Berenguer, I Ramos-Álvarez… - Biochimica et Biophysica …, 2016 - Elsevier
In a recent study we explored Group-1-p21-activated kinases (GP. 1-PAKs) in rat pancreatic
acini. Only PAK2 was present; it was activated by gastrointestinal-hormones …
acini. Only PAK2 was present; it was activated by gastrointestinal-hormones …
[HTML][HTML] CCK causes PKD1 activation in pancreatic acini by signaling through PKC-δ and PKC-independent pathways
Protein kinase D1 (PKD1) is involved in cellular processes including protein secretion,
proliferation and apoptosis. Studies suggest PKD1 is activated by various stimulants …
proliferation and apoptosis. Studies suggest PKD1 is activated by various stimulants …
Cholecystokinin-stimulated protein kinase C-δ kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar …
Protein kinase C-δ (PKC-δ) is involved in growth, differentiation, tumor suppression, and
regulation of other cellular processes. PKC-δ activation causes translocation, tyrosine …
regulation of other cellular processes. PKC-δ activation causes translocation, tyrosine …