Coronary Plaque Erosion: Epidemiology, Diagnosis, and Treatment

P Theofilis, PK Vlachakis, A Papanikolaou… - International Journal of …, 2024 - mdpi.com
Plaque erosion (PE), a distinct etiology of acute coronary syndromes (ACSs), is often
overshadowed by plaque ruptures (PRs). Concerning its epidemiology, PE has garnered …

Risk Factors Favoring Plaque Erosion

T Hamana, P Shah, A Grogan, R Kawakami… - Current Atherosclerosis …, 2024 - Springer
Risk Factors Favoring Plaque Erosion | Current Atherosclerosis Reports Skip to main content
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Endothelial shear stress metrics associate with proinflammatory pathways at the culprit site of coronary erosion

ME Ahmed, DM Leistner, D Hakim… - Basic to Translational …, 2024 - jacc.org
Low endothelial shear stress (ESS) and associated adverse biomechanical features
stimulate inflammation, contribute to atherogenesis, and predispose to coronary plaque …

Erosion of the Atheroma: Wicked T Cells at the Culprit Site

S Lin, Y Yu, LÅ Söderström, A Gisterå - Current Atherosclerosis Reports, 2024 - Springer
Erosion of the Atheroma: Wicked T Cells at the Culprit Site | Current Atherosclerosis Reports
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Unraveling the complex interplay between abnormal hemorheology and shape asymmetry in flow through stenotic arteries

S Chakraborty, VT Mantripragada… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective: Stenosis or narrowing of arteries due to the buildup of
plaque is a common occurrence in atherosclerosis and coronary artery disease (CAD) …

[HTML][HTML] Extracellular vesicles originating from the mechanical microenvironment in the pathogenesis and applications for cardiovascular diseases

Y Zeng, X Cui, H Li, Y Wang, M Cheng, X Zhang - Regenerative Therapy, 2024 - Elsevier
The mechanical microenvironment plays a crucial regulatory role in the growth and
development of cells. Mechanical stimuli, including shear, tensile, compression, and …

Spatial patterns of high-risk biomechanical metrics in plaques with abnormal vs. normal physiological flow indices

D Hakim, M Ahmed, AU Coskun, C Maynard… - International Journal of …, 2025 - Elsevier
Background Plaques associated with abnormally low physiological flow reserve indices are
appropriate for percutaneous coronary intervention (PCI). However, recent trials …

The plaque hypothesis: understanding mechanisms of plaque progression and destabilization, and implications for clinical management

ME Ahmed, D Hakim, PH Stone - Current Opinion in Cardiology, 2023 - journals.lww.com
Local plaque topography, hemodynamic patterns, and internal plaque constituents
constitute high-risk features that may be located along the entire course of the coronary …

[HTML][HTML] Linking Physiology and Biology in Plaque Erosion: A Gordian Knot

CV Bourantas, R Torii, PW Serruys - Basic to Translational Science, 2024 - jacc.org
Developments in invasive and noninvasive imaging have enabled in vivo characterization of
plaque phenotypes and allowed more accurate stratification of cardiovascular risk …

High-Resolution Iodine-enhanced Micro-Computed Tomography of Intact Human Hearts for Detailed Coronary Microvasculature Analysis

J Reifart, P Iaizzo - 2024 - preprints.org
Abstract Current Micro-Computed Tomography (Micro-CT) protocols for microvasculature
analysis often necessitate organ dissection and non-clearable contrast agents. We describe …