A review of the role of serotonin system genes in obsessive-compulsive disorder

VM Sinopoli, CL Burton, S Kronenberg… - … & Biobehavioral Reviews, 2017 - Elsevier
Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder that causes
the patient to experience intrusive thoughts and/or to carry out repetitive, ritualized behaviors …

Genetic and epigenetic architecture of obsessive-compulsive disorder: in search of possible diagnostic and prognostic biomarkers

F Bellia, M Vismara, E Annunzi, C Cifani… - Journal of psychiatric …, 2021 - Elsevier
Abstract Obsessive-Compulsive Disorder (OCD) is a prevalent and severe clinical condition
whose hallmarks are excessive, unwanted thoughts (obsessions) and repetitive behaviors …

Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study

E Voyiaziakis, O Evgrafov, D Li, HJ Yoon… - Molecular …, 2011 - nature.com
Genetic association studies of SLC6A4 (SERT) and obsessive-compulsive disorder (OCD)
have been equivocal. We genotyped 1241 individuals in 278 pedigrees from the OCD …

Molecular genetics of monoamine transporters: relevance to brain disorders

K Haddley, AS Vasiliou, FR Ali, UM Paredes… - Neurochemical …, 2008 - Springer
We have demonstrated in both the human serotonin transporter gene (5HTT) and the
dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable …

New evidence of heterogeneity in social anxiety disorder: Defining two qualitatively different personality profiles taking into account clinical, environmental and genetic …

C Binelli, A Muñiz, S Sanches, A Ortiz… - European …, 2015 - cambridge.org
Purpose: To study qualitatively different subgroups of social anxiety disorder (SAD) based
on harm avoidance (HA) and novelty seeking (NS) dimensions. Method: One hundred and …

Association study between obsessive–compulsive disorder and serotonergic candidate genes

PA Saiz, MP Garcia-Portilla, C Arango… - Progress in Neuro …, 2008 - Elsevier
BACKGROUND: To date, research examining the relationship between serotonergic genes
and obsessive–compulsive disorder (OCD) has yielded conflicting results. The purpose of …

How specific are inhibitory deficits to obsessive-compulsive disorder? A neurophysiological comparison with panic disorder

SJ Thomas, CJ Gonsalvez, SJ Johnstone - Clinical Neurophysiology, 2014 - Elsevier
Objective Impaired inhibition may perpetuate repetitive symptoms in obsessive-compulsive
disorder (OCD), however OCD-specific deficits have yet to be established. We investigated …

Behavioural genetics of the serotonin transporter

K Haddley, VJ Bubb, G Breen… - Behavioral …, 2012 - Springer
The serotonin transporter is a key regulator of the bioavailability of serotonin and therefore
any modulation in the expression or action of the transporter would be expected to have …

How neuroscience and behavioral genetics improve psychiatric assessment: report on a violent murder case

D Rigoni, S Pellegrini, V Mariotti, A Cozza… - Frontiers in behavioral …, 2010 - frontiersin.org
Despite the advances in the understanding of neural and genetic foundations of violence,
the investigation of the biological bases of a mental disorder is rarely included in psychiatric …

Association analysis of SLC6A4 and HTR2A genes with obsessive-compulsive disorder: Influence of the STin2 polymorphism

CKF Gomes, T Vieira-Fonseca, FB Melo-Felippe… - Comprehensive …, 2018 - Elsevier
Abstract Background Obsessive-Compulsive Disorder (OCD) is a complex and chronic
disorder characterized by recurrent thoughts and/or repetitive behaviors. Given the potent …