Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …

Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Due to the rising prevalence of obesity and type II diabetes mellitus, non‐alcoholic fatty liver
disease is becoming the leading cause of chronic liver disease in the Western world. In …

Background Weight loss is often key in the management of obese or overweight patients
with type 2 diabetes, yet few treatments for diabetes achieve clinically meaningful weight …

The enteroendocrine system orchestrates how the body responds to the ingestion of foods,
employing a diversity of hormones to fine-tune a wide range of physiological responses both …

Abstract Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays
a central role in the coordination of postprandial glucose homeostasis through actions on …

Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This
action has been attributed to activation of the G protein–coupled bile acid receptor GPBAR1 …

Background Roux-en-Y gastric bypass (RYGB) is an effective means to achieve sustained
weight loss for morbidly obese individuals. Besides rapid weight reduction, patients achieve …