Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments

SN Lone, S Nisar, T Masoodi, M Singh, A Rizwan… - Molecular cancer, 2022 - Springer
Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly
being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have …

Circulating tumor cell isolation, culture, and downstream molecular analysis

S Sharma, R Zhuang, M Long, M Pavlovic, Y Kang… - Biotechnology …, 2018 - Elsevier
Circulating tumor cells (CTCs) are a major contributor of cancer metastases and hold a
promising prognostic significance in cancer detection. Performing functional and molecular …

Size-based separation methods of circulating tumor cells

SJ Hao, Y Wan, YQ Xia, X Zou, SY Zheng - Advanced drug delivery reviews, 2018 - Elsevier
Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the
peripheral bloodstream. Compared to other “liquid biopsy” portfolios such as exosome …

Rare cell isolation and analysis in microfluidics

Y Chen, P Li, PH Huang, Y Xie, JD Mai, L Wang… - Lab on a Chip, 2014 - pubs.rsc.org
Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

Emerging role of nanomaterials in circulating tumor cell isolation and analysis

HJ Yoon, M Kozminsky, S Nagrath - ACS nano, 2014 - ACS Publications
Circulating tumor cells (CTCs) are low frequency cells found in the bloodstream after having
been shed from a primary tumor. These cells are research targets because of the information …

Integrated “lab-on-a-chip” microfluidic systems for isolation, enrichment, and analysis of cancer biomarkers

S Surappa, P Multani, U Parlatan, PD Sinawang… - Lab on a Chip, 2023 - pubs.rsc.org
The liquid biopsy has garnered considerable attention as a complementary clinical tool for
the early detection, molecular characterization and monitoring of cancer over the past …

Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

JM Jackson, MA Witek, JW Kamande… - Chemical Society …, 2017 - pubs.rsc.org
We present a critical review of microfluidic technologies and material effects on the analyses
of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients …

Microfluidic blood cell sorting: now and beyond

ZTF Yu, KM Aw Yong, J Fu - Small, 2014 - Wiley Online Library
Blood plays an important role in homeostatic regulation with each of its cellular components
having important therapeutic and diagnostic uses. Therefore, separation and sorting of …

Enrichment, detection and clinical significance of circulating tumor cells

SK Arya, B Lim, ARA Rahman - Lab on a Chip, 2013 - pubs.rsc.org
Circulating Tumor Cells (CTCs) are shed from primary or secondary tumors into blood
circulation. Accessing and analyzing these cells provides a non-invasive alternative to tissue …

Fast and efficient microfluidic cell filter for isolation of circulating tumor cells from unprocessed whole blood of colorectal cancer patients

S Ribeiro-Samy, MI Oliveira, T Pereira-Veiga… - Scientific reports, 2019 - nature.com
Liquid biopsy offers unique opportunities for low invasive diagnosis, real-time patient
monitoring and treatment selection. The phenotypic and molecular profile of circulating …