Current drugs for HIV-1: from challenges to potential in HIV/AIDS
Y Peng, Y Zong, D Wang, J Chen, ZS Chen… - Frontiers in …, 2023 - frontiersin.org
The human immunodeficiency virus (HIV) persists in latently infected CD4+ T cells and
integrates with the host genome until cell death. Acquired immunodeficiency syndrome …
integrates with the host genome until cell death. Acquired immunodeficiency syndrome …
[HTML][HTML] New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs
M Marra, A Catalano, MS Sinicropi, J Ceramella… - Viruses, 2024 - mdpi.com
More than 80 million people worldwide have been infected with the human
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …
Preparation of a key intermediate en route to the anti-HIV drug lenacapavir
A very efficient four-step synthesis of the main fragment of Gilead's anti-HIV drug lenacapavir
is described. The route showcases a 1, 2-addition to an intermediate aldehyde using an …
is described. The route showcases a 1, 2-addition to an intermediate aldehyde using an …
A Review of FDA-Approved Anti-HIV-1 Drugs, Anti-Gag Compounds, and Potential Strategies for HIV-1 Eradication
Acquired immunodeficiency syndrome (AIDS) is an enormous global health threat stemming
from human immunodeficiency virus (HIV-1) infection. Up to now, the tremendous advances …
from human immunodeficiency virus (HIV-1) infection. Up to now, the tremendous advances …
Preparation of a key intermediate en route to the anti-HIV drug lenacapavir
A very efficient 4-step synthesis of the main fragment of Gilead's anti-HIV drug lenacapavir is
described. The route showcases a 1, 2-addition to an intermediate aldehyde using an …
described. The route showcases a 1, 2-addition to an intermediate aldehyde using an …
An Engineered Aminotransferase for the Synthesis of a Key Chiral Intermediate of Lenacapavir
We report the development of an engineered aminotransferase for the synthesis of a key
chiral intermediate of the anti-HIV drug Lenacapavir. Due to the sterically demanding nature …
chiral intermediate of the anti-HIV drug Lenacapavir. Due to the sterically demanding nature …