Recent advances in the synthesis, stability, and activation of platinum (IV) anticancer prodrugs
Platinum-based anticancer drugs have been widely applied in clinical settings for more than
40 years. The remarkable breakthroughs that have come from the use of these complexes in …
40 years. The remarkable breakthroughs that have come from the use of these complexes in …
Halogenated PtIV Complexes from N‐Halosuccinimide Oxidation of PtII Antitumor Drugs: Synthesis, Mechanistic Investigation, and Cytotoxicity
Z Xu, C Li, Z Tong, L Ma, MK Tse… - European Journal of …, 2017 - Wiley Online Library
Compared with square‐planar PtII drugs, PtIV‐based anticancer prodrugs are relatively inert
under physiological conditions and can be activated after entering cells. The two axial …
under physiological conditions and can be activated after entering cells. The two axial …
Synthesis and reactivity of cytotoxic platinum (II) complexes of bidentate oximes–A step towards the functionalization of bioactive complexes
D Belli Dell'Amico, M Colalillo… - European Journal of …, 2018 - Wiley Online Library
Two new platinum (II) complexes bearing triphenylphosphine and bidentate oxime ligands
[Pt (Cl)(PPh3){(κ2‐N, O)‐(1 {C (R)= N (OH)‐2 (O) C10H6})}](R= H, Me) were synthesized in …
[Pt (Cl)(PPh3){(κ2‐N, O)‐(1 {C (R)= N (OH)‐2 (O) C10H6})}](R= H, Me) were synthesized in …
Synthesis and reactivity of platinum (II) triphenylphosphino complexes with aromatic aldoximes
DB Dell'Amico, M Colalillo, L Labella, F Marchetti… - Inorganica Chimica …, 2018 - Elsevier
Abstract trans-[Pt (μ-Cl) Cl (PPh 3)] 2 reacted with arylaldoximes in 1, 2-dichloroethane to
afford [PtCl 2 (PPh 3){N (OH) double bondCHAr}](Ar= 3, 4-dimethoxyphenyl, 1-naphthyl, 9 …
afford [PtCl 2 (PPh 3){N (OH) double bondCHAr}](Ar= 3, 4-dimethoxyphenyl, 1-naphthyl, 9 …