Glutathione S-conjugates as prodrugs to target drug-resistant tumors

EE Ramsay, PJ Dilda - Frontiers in pharmacology, 2014 - frontiersin.org
Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic
detoxification in many species is the conjugation of activated xenobiotics to reduced …

Genetic polymorphism in glutathione transferases (GST): population distribution of GSTM1, T1, and P1 conjugating activity

G Ginsberg, S Smolenski, D Hattis… - Journal of Toxicology …, 2009 - Taylor & Francis
Glutathione transferases (GST) catalyze the conjugation of glutathione (GSH) with
electrophiles, many of which may otherwise interact with protein or DNA. In select cases …

Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides

C Costa, JP Teixeira, S Silva, J Roma-Torres… - …, 2006 - academic.oup.com
Widespread use of pesticides in agriculture represents a threat not only to the environment
but also to human populations exposed to them. Many of these compounds are capable of …

Occupational exposure to formaldehyde and early biomarkers of cancer risk, immunotoxicity and susceptibility

S Costa, C Costa, J Madureira, V Valdiglesias… - Environmental …, 2019 - Elsevier
Formaldehyde (FA) is a high-volume production chemical manufactured worldwide to which
many people are exposed to both environmentally and occupationally. FA was recently …

Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde

S Costa, P Coelho, C Costa, S Silva, O Mayan… - Toxicology, 2008 - Elsevier
Formaldehyde (FA) is a chemical traditionally used in pathology and anatomy laboratories
as a tissue preservative. Several epidemiological studies of occupational exposure to FA …

Ghrelin and lipid metabolism: key partners in energy balance

L Varela, MJ Vázquez, F Cordido… - Journal of …, 2011 - jme.bioscientifica.com
It is widely accepted that thyroid cancer is strongly determined by the individual genetic
background. In this regard, it is expected that sporadic thyroid cancer is the result of multiple …

Is organic farming safer to farmers' health? A comparison between organic and traditional farming

C Costa, J García-Lestón, S Costa, P Coelho, S Silva… - Toxicology letters, 2014 - Elsevier
Exposure to pesticides is a major public health concern, because of the widespread
distribution of these compounds and their possible long term effects. Recently, organic …

Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde

S Costa, S Carvalho, C Costa, P Coelho, S Silva… - …, 2015 - academic.oup.com
Formaldehyde (FA) is a commonly used chemical in anatomy and pathology laboratories as
a tissue preservative and fixative. Because of its sensitising properties, irritating effects and …

The influence of the environment on the development of thyroid tumors: a new appraisal

MA Marcello, P Malandrino… - Endocrine-related …, 2014 - erc.bioscientifica.com
Most epidemiological studies concerning differentiated thyroid cancers (DTC) indicate an
increasing incidence over the last two decades. This increase might be partially explained …

Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer

E Adjadj, M Schlumberger, F de Vathaire - The lancet oncology, 2009 - thelancet.com
The incidence of differentiated thyroid carcinoma (DTC) is increasing in most developed
countries. The only well-known risk factor for thyroid cancer is exposure to ionising radiation …