Analysis of the evolution, localization and biologic function of papain family cysteine
proteases in metazoan and protozoan parasites has provided important and often surprising …

Infestation with parasitic helminths is a common problem in human populations of third world
countries and is ubiquitous in livestock and other domestic animals. The cell-membrane …

Twenty-seven Trypanosoma cruzi strains, susceptible or naturally resistant to the
nitroderivatives benznidazole and nifurtimox, were analyzed using the following molecular …

Resistance to currently used drugs is a serious problem in most fields of antimicrobial
chemotherapy. Crossresistance between two of the major classes of drug used in the …

The ATP-binding cassette (ABC) superfamily is one of the largest protein families with
representatives in all kingdoms of life. Members of this superfamily are involved in a wide …

Parasitic protozoa are responsible for a wide spectrum of diseases in humans and domestic
animals. The main line of defence available against these organisms is chemotherapy …

Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless
therapeutic failures of BZ have been reported, which were mostly attributed to variable drug …

Protozoan parasites are responsible for important diseases that threaten the lives of nearly
one-quarter of the human population world-wide. Among them, leishmaniasis has become …

Drug resistance in African trypanosomes has been studied for almost a hundred years.
Beginning with Paul Ehrlich's work that led to the chemoreceptor hypothesis, reduction of net …

Trypanosoma cruzi is the protozoan parasite that causes Chagas' disease, a frequently fatal
illness affecting the heart and gastrointestinal systems. An estimated 16 million to 18 million …