Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The
production and deposition of Aβ are important factors affecting AD progression and …

Microglial function declines during aging. The interaction of microglia with the gut microbiota
has been well characterized during development and adulthood but not in aging. Here, we …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Advanced glycation end products (AGEs) are stable posttranslational modifications of
proteins formed by the spontaneous reaction with glucose and related metabolites …

Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of
reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed …

Glycation is both a physiological and pathological process which mainly affects proteins,
nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious …

The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

The receptor for advanced glycation endproducts (RAGE) was first described as a signal
transduction receptor for advanced glycation endproducts (AGEs), the products of …

The enhanced generation and accumulation of advanced glycation endproducts (AGEs)
have been linked to increased risk for macrovascular and microvascular complications …