Application of biocompatible drug delivery nanosystems for the treatment of naturally occurring cancer in dogs

N Ambrosio, S Voci, A Gagliardi, E Palma… - Journal of Functional …, 2022 - mdpi.com
Background: Cancer is a common disease in dogs, with a growing incidence related to the
age of the animal. Nanotechnology is being employed in the veterinary field in the same …

Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer

JL Miller, AP Bartlett, RM Harman, PD Majhi… - Journal of Mammary …, 2022 - Springer
Mammary cancer, or breast cancer in women, is a polygenic disease with a complex
etiopathogenesis. While much remains elusive regarding its origin, it is well established that …

Development and pathology of the equine mammary gland

K Hughes - Journal of mammary gland biology and neoplasia, 2021 - Springer
An understanding of the anatomy, histology, and development of the equine mammary
gland underpins study of the pathology of diseases including galactorrhoea, agalactia …

Establishment and characterization of equine mammary organoids using a method translatable to other non-traditional model species

AP Bartlett, RM Harman, JR Weiss… - …, 2022 - journals.biologists.com
Mammary organoid (MaO) models are only available for a few traditional model organisms,
limiting our ability to investigate mammary gland development and cancer across mammals …

Translational oncotargets for immunotherapy: From pet dogs to humans

LA Mestrinho, RR Santos - Advanced Drug Delivery Reviews, 2021 - Elsevier
Preclinical studies in rodent models have been a pivotal role in human clinical research, but
many of them fail in the translational process. Spontaneous tumors in pet dogs have the …

Expanding the Evo-Devo Toolkit: Generation of 3D mammary tissue from diverse mammals

HY Kim, I Sinha, KE Sears, C Kuperwasser… - …, 2024 - journals.biologists.com
The varying pathways of mammary gland development across species and evolutionary
history are underexplored, largely due to a lack of model systems. Recent progress in …

Using organoids to tap mammary gland diversity for novel insight

G Rauner - Journal of Mammary Gland Biology and Neoplasia, 2024 - Springer
This article offers a comprehensive perspective on the transformative role of organoid
technology on mammary gland biology research across a diverse array of mammalian …

Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos

L Guo, L Kruglyak - Physiological Genomics, 2023 - journals.physiology.org
Although there are more than 10,000 reptile species, and reptiles have historically
contributed to our understanding of biology, genetics research into class Reptilia has lagged …

A xenotransplantation mouse model to study physiology of the mammary gland from large mammals

JL Miller, A Reddy, RM Harman, GR Van de Walle - Plos one, 2024 - journals.plos.org
Although highly conserved in structure and function, many (patho) physiological processes
of the mammary gland vary drastically between mammals, with mechanisms regulating …

The ecology of cancer prevalence across species: Cancer prevalence is highest in desert species and high trophic levels

SE Kapsetaki, Z Compton, SM Rupp, MM Garner… - bioRxiv, 2022 - biorxiv.org
The ecology in which species live and evolve likely affects their health and vulnerability to
diseases including cancer. Using 14,267 necropsy records across 244 vertebrate species …